herg channel — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9009	ICA-105574	ICA,3-nitro-N-[4-phenoxyphenyl]-benzamide	HER
	ICA-105574 (ICA) is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel.		HER
T11966	MCHR1 antagonist 2		HER , Melanin-concentrating Hormone Receptor (MCHR)
	MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.		HER , Melanin-concentrating Hormone Receptor (MCHR)
T1278	Astemizole	Laridal,Histaminos,Paralergin	Potassium Channel , Histamine Receptor
	Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to re...		Potassium Channel , Histamine Receptor
T1496	Amiodarone hydrochloride	Amiodar,Amiodarone HCl,Nexterone	Potassium Channel , Adrenergic Receptor , Autophagy
	Amiodarone hydrochloride (Amiodarone HCl) is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM C...		Potassium Channel , Adrenergic Receptor , Autophagy
T4641	Branaplam	LMI 070,NVS-SM1	Others , Potassium Channel , DNA/RNA Synthesis
	Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator.		Others , Potassium Channel , DNA/RNA Synthesis
T7198	E-4031		EGFR , Potassium Channel
	E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)		EGFR , Potassium Channel
T1676	Rosuvastatin	ZD 4522	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin (ZD 4522) is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting...		Potassium Channel , HMG-CoA Reductase , Autophagy
T1510	Rosuvastatin calcium	ZD 4522 Calcium,ZD4522,Rosuvastatin hemicalcium	Potassium Channel , HMG-CoA Reductase , Autophagy
	Rosuvastatin calcium (ZD4522) , a selective and competitive inhibitor of hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, has antilipidemic activity.		Potassium Channel , HMG-CoA Reductase , Autophagy
T0801	Tannic acid	Gallotannic acid	Potassium Channel , HER , CXCR
	Tannic acid (Gallotannic acid) is a novel hERG channel blocker.		Potassium Channel , HER , CXCR
T16444	PD-118057		Potassium Channel , HER
	PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential ...		Potassium Channel , HER
T7195	GSK369796 Dihydrochloride	N-tert-butylisoquine	Potassium Channel , Parasite
	GSK369796 Dihydrochloride (N-tert-butylisoquine),is an anti-malaria drug candidate. is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization(IC50 of 7.5 μM)		Potassium Channel , Parasite
T14077	A-935142		EGFR
	A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator. a-935142 enhances hERG currents by slowing inactivation, promoting activation, reducing inactivation, shortening atrial and ventricular re...		EGFR
T3192	NS1643		Potassium Channel , HER , Autophagy
	NS1643 is a potent human ether-a-go-go related gene (hERG) KV11.1 channel activator with EC50 of 10.5 μM.		Potassium Channel , HER , Autophagy
T83979	Sulcardine 2HCl	Sulcardine 2HCl（343935-60-4 Free base）,HBI-3000 2HCl
	Sulcardine 2HCl is a multi-ion channel blocker with antiarrhythmic effects that blocks the properties of hERG and hNav1.5 channels and can be used to study atrial fibrillation and ventricular arrhythmias.
T10335	Antihistamine-1		P450
	Antihistamine-1 is an H1-antihistamine (Ki: 6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel (IC50s: 5.4 and 0.8 μM).		P450
T6175	ADL-5859	ADL5859 Hydrochloride,ADL5859 HCl	Opioid Receptor
	ADL-5859 (ADL5859 Hydrochloride) is a selective δ-opioid receptor agonist ( Ki: 0.8 nM), selectivity against opioid receptor κ, μ, and little inhibition for the hERG channel.		Opioid Receptor
T30260	AZD-5672	AZD 5672,AZD5672,UNII-61XQN688TW	HER , P-gp , CCR
	AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7.3 μM and 32 μM. AZD-5672 can be used in studies about rheu...		HER , P-gp , CCR
T8182	Guanfu base A	Guan-fu base A	P450 , Potassium Channel , HER
	Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.		P450 , Potassium Channel , HER
T16265	Naluzotan	PRX 00023	EGFR , 5-HT Receptor
	Naluzotan（PRX 00023） is a novel and potent 5-HT1A agonist with IC50 and Ki values of approximately 20 nM and 5.1 nM, respectively.Naluzotan is a potent hERG K+ channel blocker with an IC50 value of 3800 nM.Naluzotan exhi...		EGFR , 5-HT Receptor
T27117	DA-6886	DA6886,DA 6886	5-HT Receptor
	DA-6886 is an agonist 5-Hydroxytryptamine receptor 4 (5-HT4). DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressin...		5-HT Receptor